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Total 224 results found since Jan 2013.

COVID-19 Vaccination Effectiveness in the General Population of an Italian Province: Two Years of Follow-Up
Vaccines (Basel). 2023 Aug 4;11(8):1325. doi: 10.3390/vaccines11081325.ABSTRACTWe carried out a cohort study on the overall population of the province of Pescara, Italy, to assess the real-world effectiveness of SARS-CoV-2 vaccination against infection, severe, or lethal COVID-19, two years after the start of the vaccination campaign. We included all the resident or domiciled subjects, and extracted the official demographic, vaccination, COVID-19, hospital and co-pay exemption datasets from 1 January 2021, up to 15 February 2023. Cox proportional hazards analyses were adjusted for gender, age, diabetes, hypertension, COPD,...
Source: Cancer Control - August 26, 2023 Category: Cancer & Oncology Authors: Annalisa Rosso Maria Elena Flacco Graziella Soldato Giuseppe Di Martino Cecilia Acuti Martellucci Roberto Carota Marco De Benedictis Graziano Di Marco Rossano Di Luzio Matteo Fiore Antonio Caponetti Lamberto Manzoli Source Type: research

Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance
CONCLUSION: We demonstrate impaired immunity following SARS-CoV-2 mRNA immunization in a murine model of comorbid T2DM and obesity, supporting the need for further research into the basis for impaired anti-SARS-CoV-2 immunity in T2DM and investigation of novel approaches to enhance vaccine immunogenicity among those with metabolic diseases.PMID:37595760 | DOI:10.1016/j.jaci.2023.06.031
Source: Clinical Lung Cancer - August 18, 2023 Category: Cancer & Oncology Authors: Timothy R O'Meara Etsuro Nanishi Marisa E McGrath Soumik Barman Danica Dong Carly Dillen Manisha Menon Hyuk-Soo Seo Sirano Dhe-Paganon Robert K Ernst Ofer Levy Matthew B Frieman David J Dowling Source Type: research

Fight Aging! Newsletter, August 14th 2023
This study demonstrates just how vital the thymus is to maintaining adult health." « Back to Top Does Amyloid-β Aggregation Cause Broad Disruption of Proteostasis? https://www.fightaging.org/archives/2023/08/does-amyloid-%ce%b2-aggregation-cause-broad-disruption-of-proteostasis/ Researchers here speculate on the ability of insoluble amyloid-β aggregates to be broadly disruptive of the solubility of many other proteins, and thus disruptive to cell and tissue function. Is this important in aging? The evidence here shows the existence of the mechanism in a lower species, but that doesn't n...
Source: Fight Aging! - August 13, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The most common gastrointestinal alterations in patients with post-COVID syndrome
CONCLUSION: We identified female gender, obesity, cardiovascular diseases, cancer, hypertension and diabetes as major risk factors of post-COVID syndrome. Vaccinated status may prevent post-COVID gastrointestinal symptoms. Orv Hetil. 2023; 164(31): 1206-1212.PMID:37543972 | DOI:10.1556/650.2023.32839
Source: Orvosi Hetilap - August 6, 2023 Category: General Medicine Authors: Kata Angyal Anna Mandula Tajthy B álint Drácz P ál Miheller Mikl ós Horváth Hajnal Sz ékely Veronika Papp Di ána Czompa Attila Szij ártó Kl ára Werling Source Type: research

COVID-19 Antibody Response in Patients with Thalassemia
Conclusion Patients with TDT manifest with mild or asymptomatic COVID-19 and mount a comparable IgG antibody response to COVID-19 akin to controls. However, this serological response could not sustain over three to six months advocating the need for protection through vaccination.PMID:37465812 | PMC:PMC10351617 | DOI:10.7759/cureus.40567
Source: Cancer Control - July 19, 2023 Category: Cancer & Oncology Authors: Nidhi Kumari Sunil Gomber Pooja Dewan Shiva Narang Rafat Ahmed Source Type: research

Fight Aging! Newsletter, July 17th 2023
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues. Resistance Exercise Slows the Onset of Pathology in a Mouse Model of Alzheimer's Disease https://www.fightaging.org/archives/2023/07/resistance-exercise-slows-the-onset-of-pathology-in-a-mouse-model-of-alzheimers-disease/ With the caveat that mouse models of Alzheimer's...
Source: Fight Aging! - July 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Clinical and Demographic Factors Associated With COVID-19, Severe COVID-19, and SARS-CoV-2 Infection in Adults: A Secondary Cross-Protocol Analysis of 4 Randomized Clinical Trials
CONCLUSIONS AND RELEVANCE: In this secondary cross-protocol analysis of 4 randomized clinical trials, exposure and demographic factors had the strongest associations with outcomes; results could inform mitigation strategies for SARS-CoV-2 and viruses with comparable epidemiological characteristics.PMID:37440227 | DOI:10.1001/jamanetworkopen.2023.23349
Source: Cancer Control - July 13, 2023 Category: Cancer & Oncology Authors: Deborah A Theodore Angela R Branche Lily Zhang Daniel S Graciaa Madhu Choudhary Timothy J Hatlen Raadhiya Osman Tara M Babu Samuel T Robinson Peter B Gilbert Dean Follmann Holly Janes James G Kublin Lindsey R Baden Paul Goepfert Glenda E Gray Beatriz Grin Source Type: research

Mushroom β-glucans: application and innovation for food industry and immunotherapy
Appl Microbiol Biotechnol. 2023 Jul 6. doi: 10.1007/s00253-023-12656-4. Online ahead of print.ABSTRACTAmong the most important sources of β-glucans are edible and medicinal mushrooms. These molecules are components of the cellular wall of basidiomycete fungi (mushrooms) and can be extracted even from the basidiocarp as the mycelium and its cultivation extracts or biomasses. Mushroom β-glucans are recognized by their potential effects as immunostimulants and immunosuppressants. They are highlighted as anticholesterolemic, anti-inflammatory, adjuvant in diabetes mellitus, mycotherapy for cancer treatment, as well as adjuva...
Source: Applied Microbiology and Biotechnology - July 6, 2023 Category: Microbiology Authors: Thayn ã Gonçalves Timm Tania Maria Costa Michele Debiasi Alberton Cristiane Vieira Helm Lorena Benathar Ballod Tavares Source Type: research